Using AWS I have,

* c5n.metal instance
* running 64-bit x86 Amazon Linux 2 AMI (HVM) - Kernel 5.10 (
ami-0ed9277fb7eb570c9)
* DPDK 22.03-rc0
* I've installed the ena kernel fix in
https://github.com/amzn/amzn-drivers/tree/master/userspace/dpdk/enav2-vfio-patch

I add a second NIC to the instance in the normal way.

This second NIC starts UP. So I bring the NIC down and bind it:

* lspci | grep Eth
7e:00.0 Ethernet controller: Amazon.com, Inc. Elastic Network Adapter (ENA)
7f:00.0 Ethernet controller: Amazon.com, Inc. Elastic Network Adapter (ENA)

* sudo ip link set eth1 down

Then I bind:

*  sudo ./dpdk-devbind.py -b vfio-pci 7f:00.0
Error: bind failed for 0000:7f:00.0 - Cannot bind to driver vfio-pci:
[Errno 19] No such device

The error seems to arise from when attempting to close the file descriptor
on /sys/bus/pci/drivers/vfio-pci/bind

dpdk-devbind.py never shows the device bound to vfio:

* sudo ./dpdk-devbind.py -s

Other Network devices
=====================
0000:7f:00.0 'Elastic Network Adapter (ENA) ec20' unused=ena,vfio-pci